Abstract
Many ligands have been described that interact with specific receptors on cells, with subsequent effects on cellular physiology. Recent advances in immunology and molecular biology have greatly enhanced our understanding of how ligands and receptors interact. The development of both polyclonal and monoclonal antireceptor antibodies has allowed the isolation and subsequent characterization of a wide variety of receptor structures. Molecular cloning techniques have allowed the elucidation of the primary amino acid sequences of many receptors and their cognate ligands. Here we describe a method for the development of receptor binding peptides based on the primary structure of antireceptor antibodies.
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Williams, W., Weiner, D., Cohen, J. et al. Development and Use of Receptor Binding Peptides Derived From Antireceptor Antibodies. Nat Biotechnol 7, 471–475 (1989). https://doi.org/10.1038/nbt0589-471
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DOI: https://doi.org/10.1038/nbt0589-471
