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Overpowering the component problem

Synthetic gene networks can be readily redesigned using new libraries of quantitatively characterized promoters coupled with predictive mathematical modeling.

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Figure 1: Design and redesign of a synthetic gene network.

Katie Vicari


  1. 1

    Dyson, F. Nature 427, 297 (2004).

    CAS  Article  Google Scholar 

  2. 2

    Hasty, J., McMillen, D. & Collins, J.J. Nature 420, 224–230 (2002).

    CAS  Article  Google Scholar 

  3. 3

    Ellis, T., Wang, X. & Collins, J.J. Nat. Biotechnol. 27, 465–471 (2009).

    CAS  Article  Google Scholar 

  4. 4

    Sprinzak, D. & Elowitz, M.B. Nature 438, 443–448 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Tigges, M., Marquez-Lago, T.T., Stelling, J. & Fussenegger, M. Nature 457, 309–312 (2009).

    CAS  Article  Google Scholar 

  6. 6

    Stricker, J. et al. Nature 456, 516–519 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Canton, B., Labno, A. & Endy, D. Nat. Biotechnol. 26, 787–793 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Austin, D.W. et al. Nature 439, 608–611 (2006).

    CAS  Article  Google Scholar 

  9. 9

    Isaacs, F.J., Dwyer, D.J. & Collins, J.J. Nat. Biotechnol. 24, 545–554 (2006).

    CAS  Article  Google Scholar 

  10. 10

    Andrianantoandro, E., Basu, S., Karig, D.K. & Weiss, R. Mol. Syst. Biol. 2, 2006.0028 (2006).

    Article  Google Scholar 

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Bennett, M., Hasty, J. Overpowering the component problem. Nat Biotechnol 27, 450–451 (2009).

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