Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Overpowering the component problem

Synthetic gene networks can be readily redesigned using new libraries of quantitatively characterized promoters coupled with predictive mathematical modeling.

This is a preview of subscription content

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Design and redesign of a synthetic gene network.

Katie Vicari

References

  1. 1

    Dyson, F. Nature 427, 297 (2004).

    CAS  Article  Google Scholar 

  2. 2

    Hasty, J., McMillen, D. & Collins, J.J. Nature 420, 224–230 (2002).

    CAS  Article  Google Scholar 

  3. 3

    Ellis, T., Wang, X. & Collins, J.J. Nat. Biotechnol. 27, 465–471 (2009).

    CAS  Article  Google Scholar 

  4. 4

    Sprinzak, D. & Elowitz, M.B. Nature 438, 443–448 (2005).

    CAS  Article  Google Scholar 

  5. 5

    Tigges, M., Marquez-Lago, T.T., Stelling, J. & Fussenegger, M. Nature 457, 309–312 (2009).

    CAS  Article  Google Scholar 

  6. 6

    Stricker, J. et al. Nature 456, 516–519 (2008).

    CAS  Article  Google Scholar 

  7. 7

    Canton, B., Labno, A. & Endy, D. Nat. Biotechnol. 26, 787–793 (2008).

    CAS  Article  Google Scholar 

  8. 8

    Austin, D.W. et al. Nature 439, 608–611 (2006).

    CAS  Article  Google Scholar 

  9. 9

    Isaacs, F.J., Dwyer, D.J. & Collins, J.J. Nat. Biotechnol. 24, 545–554 (2006).

    CAS  Article  Google Scholar 

  10. 10

    Andrianantoandro, E., Basu, S., Karig, D.K. & Weiss, R. Mol. Syst. Biol. 2, 2006.0028 (2006).

    Article  Google Scholar 

Download references

Author information

Affiliations

Authors

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Bennett, M., Hasty, J. Overpowering the component problem. Nat Biotechnol 27, 450–451 (2009). https://doi.org/10.1038/nbt0509-450

Download citation

Further reading

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing