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Structure-aided drug design's next generation

Has structural bioinformatics advanced enough to form the core of a drug discovery program? A new generation of companies exploiting structure-focused technologies is counting on it.

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Figure 1: Screening by X-ray crystallography.
Figure 3: Anti-targeting approach to drug dosing.
Figure 2: ACTOR robot for high throughput X-ray crystallography.

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Thiel, K. Structure-aided drug design's next generation. Nat Biotechnol 22, 513–519 (2004). https://doi.org/10.1038/nbt0504-513

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