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Structure-aided drug design's next generation

Has structural bioinformatics advanced enough to form the core of a drug discovery program? A new generation of companies exploiting structure-focused technologies is counting on it.

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Figure 1: Screening by X-ray crystallography.
Figure 3: Anti-targeting approach to drug dosing.
Figure 2: ACTOR robot for high throughput X-ray crystallography.


  1. 1

    Goldstein, J.L. Remarks at the Awards Ceremony, Albert Lasker Award for Clinical Research, 1999. 1999remarksgsclin2.shtml

  2. 2

    Shuker, S.B. et al. Discovering high-affinity ligands for proteins: SAR by NMR. Science 274, 1531–1534 (1996).

    CAS  Article  Google Scholar 

  3. 3

    Palczewski, K. et al. Crystal structure of rhodopsin: a G protein–coupled receptor. Science 289, 739–745 (2000).

    CAS  Article  Google Scholar 

  4. 4

    Levinthal, C. How to fold graciously. in Mössbauer Spectroscopy in Biological Systems. Proceedings of a Meeting Held at Allerton House, Monticello, Illinois. (eds. DeBrunner, J.T.P. & Munck, E.) 22–24 (University of Illinois Press, Chicago, IL, USA, 1969).

    Google Scholar 

  5. 5

    Williams, P. et al. Crystal structure of human cytochrome P450 2C9 with bound warfarin. Nature 424, 464–468 (2003).

    CAS  Article  Google Scholar 

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Thiel, K. Structure-aided drug design's next generation. Nat Biotechnol 22, 513–519 (2004).

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