Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Stem cell biologists sure play a mean pinball

Mouse fibroblasts are reprogrammed to functional neurons by expression of a few transcription factors.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Pinball model of development and reprogramming.

Katie Vicari

References

  1. Vierbuchen, T. et al. Nature 463, 1035–1041 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Takahashi, K. & Yamanaka, S. Cell 126, 663–676 (2006).

    CAS  PubMed  Google Scholar 

  3. Takahashi, K. et al. Cell 131, 861–872 (2007).

    Article  CAS  PubMed  Google Scholar 

  4. Zhou, Q., Brown, J., Kanarek, A., Rajagopal, J. & Melton, D.A. Nature 455, 627–632 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Izumikawa, M. et al. Nat. Med. 11, 271–276 (2005).

    Article  CAS  PubMed  Google Scholar 

  6. Xie, H., Ye, M., Feng, R. & Graf, T. Cell 117, 663–676 (2004).

    Article  CAS  PubMed  Google Scholar 

  7. Berninger, B. et al. J. Neurosci. 27, 8654–8664 (2007).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Kim, H.J., Sugimori, M., Nakafuku, M. & Svendsen, C.N. Exp. Neurol. 203, 394–405 (2007).

    Article  CAS  PubMed  Google Scholar 

  9. Motohashi, T., Yamanaka, K., Chiba, K., Aoki, H. & Kunisada, T. Stem Cells 27, 888–897 (2009).

    Article  CAS  PubMed  Google Scholar 

  10. Toma, J.G., McKenzie, I.A., Bagli, D. & Miller, F.D. Stem Cells 23, 727–737 (2005).

    Article  CAS  PubMed  Google Scholar 

  11. Nicholas, C.R. & Kriegstein, A.R. Nature 463, 1031–1032 (2010).

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Dhruv Sareen or Clive N Svendsen.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sareen, D., Svendsen, C. Stem cell biologists sure play a mean pinball. Nat Biotechnol 28, 333–335 (2010). https://doi.org/10.1038/nbt0410-333

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt0410-333

This article is cited by

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research