The development of specific, sensitive, and simple diagnostic tests is central to molecular medicine. In this issue, Brow et al. describe a powerful new molecular tool for the analysis of the gene at the level of single nucleotides. (p. 292). They have exploited the exquisite sequence sensitivity of a Flap endonuclease from archaebacteria to allow it to report on single nucleotide changes in target genes.
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Frederickson, R. Invading diagnostics. Nat Biotechnol 17, 214 (1999). https://doi.org/10.1038/6937
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DOI: https://doi.org/10.1038/6937