Abstract
The development of a continuous fermentation system with immobilized microorganisms for manufacturing biochemicals is described. Data for Saccharomyces cerevisiae producing ethanol is used as an example of reactor kinetics. A mini-bioreactor was used to obtain the kinetic data, which is useful in designing pilot plant and production scale reactors. Electron micrographs illustrate how the yeast cells populate the IMC beads and escape into the fermentation liquor. A method using cascaded fluidized beds with individual recirculation loops for oxygenation and fluidization is described.
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Karkare, S., Dean, R. & Venkatasubramanian, K. Continuous Fermentation with Fluidized Slurries of Immobilized Microorganisms. Nat Biotechnol 3, 247–251 (1985). https://doi.org/10.1038/nbt0385-247
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DOI: https://doi.org/10.1038/nbt0385-247
