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Targeting leukemia stem cells

Nature Biotechnology volume 28, pages 237–238 (2010)Cite this article

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Acute myeloid leukemia stem cells can be made susceptible to chemotherapy by inducing them to divide.

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Figure 1: Eradication of leukemia by induction of leukemia stem cell cycling before chemotherapy.

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Author information

Authors and Affiliations

  1. Hanna K A Mikkola is in the Department of Molecular, Cell and Developmental Biology, Los Angeles, California.,

    Hanna K A Mikkola

  2. Caius G Raduis is in the Department of Medical Molecular Pharmacology, Los Angeles, California.,

    Caius G Radu

  3. Owen Witte is an investigator with the Howard Hughes Medical Institute, University of California, Los Angeles, California.,

    Owen N Witte

Authors
  1. Hanna K A Mikkola
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  2. Caius G Radu
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  3. Owen N Witte
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Corresponding author

Correspondence to Owen N Witte.

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Competing interests

C.G.R. is co-inventor on patent filings for novel PET probes for immunity and cancer based on DNA salvage pathways and co-founder and consultant to Sofie Biosciences, which is licensing this technology.

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Mikkola, H., Radu, C. & Witte, O. Targeting leukemia stem cells. Nat Biotechnol 28, 237–238 (2010). https://doi.org/10.1038/nbt0310-237

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