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Maximizing power in association studies

Only a subset of genetic variants can be examined in genome-wide surveys for genetic risk factors. How can a fixed set of markers account for the entire genome by acting as proxies for neighboring associations?

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Figure 1: TagSNPs and haplotype information can enhance the ability to identify disease-related loci using linkage disequilibrium.


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E.H. is a faculty fellow of the Edmond J. Safra Bioinformatics program at Tel Aviv Univerity.

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Halperin, E., Stephan, D. Maximizing power in association studies. Nat Biotechnol 27, 255–256 (2009).

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