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Combinatorial stem cell mobilization

Nature Biotechnology volume 27, pages 252–253 (2009)Cite this article

Different subsets of bone marrow stem cells can be mobilized by varying drug treatments.

The development of strategies to induce the release of stem cells and derivative progenitor cells from the bone marrow into the blood, a phenomenon termed mobilization, has focused almost exclusively on hematopoietic stem cells (HSCs)1,2. Thus far, there have been no reports of reproducible, efficient methods for mobilizing other stem or progenitor cells in the bone marrow, including endothelial progenitor cells (EPCs) and stromal mesenchymal progenitors, more commonly referred to as mesenchymal stem cells (MSCs). In a recent issue of Cell Stem Cell, Pitchford et al.3 outline new ways of selectively recruiting different subsets of these cell populations into the circulation, an approach that may have considerable therapeutic benefits.

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Figure 1: Regimens for differential mobilization of populations of stem and progenitor cells from the mouse bone marrow.

Kim Caesar

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Authors and Affiliations

  1. Mikhail G. Kolonin and Paul J. Simmons are at The Brown Foundation Institute of Molecular Medicine for the Prevention of Human Disease, University of Texas Health Science Center at Houston, Houston, Texas 77030, USA. Mikhail.G.Kolonin@uth.tmc.edu Paul.J.Simmons@uth.tmc.edu,

    Mikhail G Kolonin & Paul J Simmons

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  1. Mikhail G Kolonin
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  2. Paul J Simmons
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Kolonin, M., Simmons, P. Combinatorial stem cell mobilization. Nat Biotechnol 27, 252–253 (2009). https://doi.org/10.1038/nbt0309-252

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