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The ascendance of combination products

Nature Biotechnology volume 24, pages 277–280 (2006)Cite this article

Convergent technologies also dovetail with the much-presaged, but yet to be realized transformation of medical practice from disease diagnosis and treatment to disease prediction and prevention. For example, smart implants may provide a means of remotely monitoring and managing therapeutic dosing; in turn, wireless communication with implants may allow health care services for chronic disease to shift from the hospital to the home setting.

Key drivers

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Figure 1: The convergence of two or more distinct scientific disciplines is the basis of a new device, process or product.
Figure 2: Place your chips.

References

  1. Business Week (May 3, 2005).

  2. Frontline Strategic Consulting. Combination Products: An Impact Analysis on the Convergence of Medical Devices and Therapeutics (Navigant Consulting/Front Line Strategic Market Reports, San Mateo, CA, 2003).

  3. Soloninka, J. Convergent Medical Technologies Local Impacts, Global Opportunities. YORKBiotech Inaugural Meeting, Ontario, Canada, November 2-3, 2005.

    Google Scholar 

  4. Dubin, C. Drug Delivery Today, 4, (2004). published online May 2004 <http;//www.drugdeliverytech.com/cgi-bin/articles.cgi?idArticle=235>

    Google Scholar 

  5. Langer, R. & Vacanti, J.P. Science 260, 920–926 (1993).

    Article  CAS  Google Scholar 

  6. Vacanti, J.P. & Langer, R. Lancet 354 Suppl 1, SI32–34 (1999).

    Article  Google Scholar 

  7. Langer, R. & Vacanti, R. Sci. Am. 280, 86–89 (1999).

    Article  CAS  Google Scholar 

  8. Richardson, T.P., Peters, M.C., Ennett, A.B. & Mooney, D.J. Polymeric system for dual growth factor delivery. Nat. Biotechnol. 19, 1029–1034 (2001).

    Article  CAS  Google Scholar 

  9. Santini, J., Cima, M. & Langer, R. Nature 397, 335–338 (1999).

    Article  CAS  Google Scholar 

  10. Grayson, A. et al. Multi-pulse drug delivery from a resorbable polymeric microchip device. Nat. Mater. 2, 767–772 (2003).

    Article  CAS  Google Scholar 

  11. Moses, M., Brem, H. & Langer, R. Sci. Med. 9, 264–273 (2003).

    CAS  Google Scholar 

  12. Peppas, N. & Langer, R. Science 263, 1715–1720 (1994).

    Article  CAS  Google Scholar 

  13. Lendlein, A. & Langer, R. Science 296, 1673–1676 (2002).

    Article  Google Scholar 

  14. Lendlein, A., Jiang, H., Junger, O. & Langer, R. Nature 434, 879–882 (2005).

    Article  CAS  Google Scholar 

  15. Luo, D. & Saltzman, M. Nat. Biotechnol. 18, 33–37 (2000).

    Article  CAS  Google Scholar 

  16. Hwang, S., Bellocq, M. & Davis, M. Bioconjug. Chem. 12, 280–290 (2001).

    Article  CAS  Google Scholar 

  17. Affleck, D.G., Yu, L., Bull, D., Bailey, S. & Kim, S.W. Gene Ther. 8, 349–353, (2001).

    Article  CAS  Google Scholar 

  18. Gref, R. et al. Science 263, 1600–1603 (1994).

    Article  CAS  Google Scholar 

  19. Farokhzad, O. et al. Cancer Res. 64, 7668–7672 (2004).

    Article  CAS  Google Scholar 

  20. Langer, R. Sci. Am. 288, 50–57 (2003).

    Article  Google Scholar 

  21. Gardner, C., Walsh, C. & Almarsson, O. Nat. Rev. Drug Discov. 3, 926–934 (2004).

    Article  CAS  Google Scholar 

  22. Anderson, D.G., Levenberg, S. & Langer, R. Nat. Biotechnol. 22, 863–866 (2004).

    Article  CAS  Google Scholar 

  23. McGall, G. et al. Proc. Natl. Acad. Sci. USA 93, 13555–13560 (1996).

    Article  CAS  Google Scholar 

  24. Schena, M., Shalon, D., Davis, R.W. & Brown, P.O. Science 270, 467–470 (1995).

    Article  CAS  Google Scholar 

  25. Langer, R. & Tirrell, D. Nature 428, 487–492 (2004).

    Article  CAS  Google Scholar 

  26. Levy, E.I. et al. J. Invasive Cardiol. 14, 646–651 (2002)

    PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute Professor at the Massachusetts Institute of Technology, Cambridge, 02139, Massachusetts, USA

    Robert Langer

  2. Medgenesis Partners Ltd, Tel-Aviv, Israel

    Ascher Shmulewitz

Authors
  1. Ascher Shmulewitz
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  2. Robert Langer
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Shmulewitz, A., Langer, R. The ascendance of combination products. Nat Biotechnol 24, 277–280 (2006). https://doi.org/10.1038/nbt0306-277b

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