Reality and immortality—neural stem cells for therapies

Article metrics

The successful immortalization of neural progenitor cells via the overexpression of telomerase prompts several questions for those intending to develop somatic stem cell therapies for neurological disease.

Access options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Neural stem and progenitor cells: production, therapy and safety concerns.

Bob Crimi

References

  1. 1

    Roy, N.S. et al. Nat. Biotechnol. 22, 297–305 (2004).

  2. 2

    Vescovi, A.L. & Snyder, E.Y. Brain Pathol. 9, 569–598 (1999).

  3. 3

    Thomson, J.A. et al. Science 282, 1145–1147 (1998).

  4. 4

    Shamblott, M.J. et al. Proc Natl Acad Sci USA 98, 113–118 (2001).

  5. 5

    Arvidsson, A., Collin, T., Kirik, D., Kokaia, Z. & Lindvall, O. Nat. Med. 8, 963–970 (2002).

  6. 6

    Magavi, S.S., Leavitt, B.R. & Macklis, J.D. Nature 405, 951–955 (2000).

  7. 7

    Gould, E., Reeves, A.J., Graziano, M.S. & Gross, C.G. Science 286, 548–552 (1999).

  8. 8

    Parent, J.M. et al. Neurosci. 17, 3727–3738 (1997).

  9. 9

    Kornack, D.R. & Rakic, P. Science 294, 2127–2130 (2001).

  10. 10

    Monje, M.L., Toda, H., Palmer, T.D. Science 302, 1760–1765 (2003).

  11. 11

    Wichterle, H., Lieberam, I., Porter, J.A. & Jessell, T.M. Cell 110, 385–397 (2002).

  12. 12

    Kim, J.H. et al. Nature 418, 50–56 (2002).

  13. 13

    Ourednik, J., Ourednik, V., Lynch, W.P., Schachner, M. & Snyder, E.Y. Nat. Biotechnol. 20, 1103–1110 (2002).

  14. 14

    Park, K.I., Teng, Y.D. & Snyder, E.Y. Nat. Biotechnol. 20, 1111–1117 (2002).

  15. 15

    Teng, Y.D. et al. Proc. Natl. Acad. Sci. USA 99, 3024–3029 (2002).

  16. 16

    Kerr, D.A. et al. J. Neurosci. 23, 5131–5140 (2003).

  17. 17

    Zorina, T.D. et al. Stem Cells 21, 377–388 (2003).

  18. 18

    Buzanska, L. et al. J. Cell Sci. 115, 2131–2138 (2002).

  19. 19

    Chen, J. et al. Stroke 32, 2682–2688 (2001).

  20. 20

    Wagner, J. et al. Nat. Biotechnol. 17, 653–659 (1999).

  21. 21

    Song, H., Stevens, C.F. & Gage, F.H. Nature 417, 39–44 (2002).

  22. 22

    Clement, A.M., Nguyen, M.D. & Roberts, E.A. et al. Science 302, 113–117 (2003).

  23. 23

    Bruijn, L.I., Becher, M.W. & Lee, M.K. et al. Neuron 18, 327–338 (1997).

  24. 24

    Maragakis, N.J. et al. Glia 45, 133–143 (2004).

  25. 25

    Lu, P., Jones, L.L., Snyder, E.Y. & Tuszynski, M.H. Exp. Neurol. 181, 115–129 (2003).

  26. 26

    Windrem, M.S. et al. Nat. Med. 10, 93–97 (2004).

  27. 27

    Nunes, M.C. et al. Nat. Med. 9, 439–447 (2003).

Download references

Author information

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rothstein, J., Snyder, E. Reality and immortality—neural stem cells for therapies. Nat Biotechnol 22, 283–285 (2004) doi:10.1038/nbt0304-283

Download citation

Further reading