On February 10, Curagen (New Haven, CT) announced the completion of the first functional genomics map of an entire genome. The company, in collaboration with Stanley Fields at the University of Washington (Seattle), has performed a comprehensive two-hybrid analysis of protein interactions in the yeast Saccharomyces cerevisiae—the first time an analysis of the protein interactions of a complete genome has been attempted. However, many in the field note that not all possible pairwise interactions are expected to be detected with this method. Nevertheless, the news prompted an immediate 24% rise in Curagen share price. Curagen's CEO Jonathon Rothberg explains that the yeast map will function as a framework onto which a functional protein map of Drosophila (currently underway) will be layered. The intention is to draw correlation between these layers and a similar map of the entire human genome, which is set to follow 24 months after the sequence is publicly available. “No other company in the world is doing each of the layers,” says Rothburg, “We're the only one that has the synergistic approach.”