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Bacterial delivery of DNA evolves

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  1. Finlay, B.B. and Cossart, P. . 1997 Science. 216: 718–725.

    Article  Google Scholar 

  2. Dietrich, G. et al. 1998. Bio/Technology 16: 181–185.

    CAS  Google Scholar 

  3. Kaufmann, S.H. 1993. Annu. Rev. Immunol. 11: 129–163

    CAS  Article  Google Scholar 

  4. Harty, J.T., Lenz, L.L. and Bevan, M.J. . 1996. Curr. Op/n. Immunol. 8: 526–530.

    CAS  Article  Google Scholar 

  5. Portnoy, D.A. et al. 1992. Infect Immun. 60: 1263–1267.

    CAS  PubMed  PubMed Central  Google Scholar 

  6. Ikonomidis, G. et al. 1997. Vaccine 15: 433–440.

    CAS  Article  Google Scholar 

  7. Sfien, H. et al. 1995. Proc. Natl. Acad. Sci. USA 91: 3987–3991.

    Google Scholar 

  8. Frankel, F.R. etal. 1995. J. Immunol. 155: 4775–4782.

    CAS  PubMed  Google Scholar 

  9. Pan, Z.K. et al. 1995. Nat. Med. 1: 471–477.

    CAS  Article  Google Scholar 

  10. Darji, A. et al. 1997. Eur. J. Immunol. 27: 1353–1359.

    CAS  Article  Google Scholar 

  11. Lee, K.D. et al. 1996. J. Biol. Chem. 271: 7249–7252.

    CAS  Article  Google Scholar 

  12. Sizemore, D.R., Branstrom, A.A., and Sadoff, J.C. . 1995. Science 270: 299–302.

    CAS  Article  Google Scholar 

  13. Courvalin, P., Goussard, S., and Grillot-Courvalin, C. 1995. C. R. Acad. Sci. III 318:1207–1212.

    CAS  PubMed  Google Scholar 

  14. Darji, A. et al. 1997. Cell 91: 765–775

    CAS  Article  Google Scholar 

  15. Taubes, G. 1997. Science 278: 1711–1714

    CAS  Article  Google Scholar 

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Higgins, D., Portnoy, D. Bacterial delivery of DNA evolves. Nat Biotechnol 16, 138–139 (1998).

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