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Make or break for costimulatory blockers

An Erratum to this article was published on 01 March 2004

An Erratum to this article was published on 29 February 2004

This article has been updated

Immunomodulator CTLA4-Ig was set to be the miracle drug for organ transplantation a dozen years ago, but then faded from view. Now, with startling results in rheumatoid arthritis, costimulatory blockers are on a comeback. Ken Garber reports.

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Figure 1: Structures of the interacting surfaces of complexes of CTLA-4 (cyan) and B7 (purple).
Figure 2: On the block.

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Garber, K. Make or break for costimulatory blockers. Nat Biotechnol 22, 145–147 (2004). https://doi.org/10.1038/nbt0204-145

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