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Dynamic allele-specific hybridization

Nature Biotechnology volume 17, pages 87–88 (1999)Cite this article

Abstract

A new method for scoring single nucleotide polymorphisms.

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Figure 1: DASH assay principle.
Figure 2: DASH model experiment.
Figure 3: Testing all SNP types.

References

  1. Stoneking, M. et al. 1991. Am. J. Hum. Genet. 48: 370–382.

    Google Scholar 

  2. Wu, D.Y. and Wallace, R.B. 1989. Genomics 4: 560–569.

    Article  Google Scholar 

  3. Syvanen, A.C. 1998. Methods Mol. Biol. 98: 291 –298.

    Google Scholar 

  4. Lipshutz, R.J. et al. 1995. BioTechniques 19: 442–447.

    Google Scholar 

  5. Heid, C.A. et al. 1996. Genome Res. 6: 986– 994.

    Article  Google Scholar 

  6. Tyagi, S. and Kramer, F.R. 1996. Nat. Biotechnol. 14: 303–308.

    Article  Google Scholar 

  7. Howley, P.M. et al. 1979. J. Biol. Chem. 254: 4876–4883.

    Google Scholar 

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Acknowledgements

We gratefully acknowledge the financial support and intellectual contributions made to this project by staff at Hybaid Ltd., UK. We are also grateful for gifts of trial plasticware provided by LabSystems in Finland, and Boehringer Mannheim in Sweden.

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Authors and Affiliations

  1. the department of genetics and pathology, Biomedical Center, Uppsala University, Box 589, Uppsala, 751 23, Sweden

    W. Mathias Howell, Magnus Jobs, Ulf Gyllensten & Anthony J. Brookes

Authors
  1. W. Mathias Howell
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  2. Magnus Jobs
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  3. Ulf Gyllensten
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  4. Anthony J. Brookes
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Correspondence to W. Mathias Howell.

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Howell, W., Jobs, M., Gyllensten, U. et al. Dynamic allele-specific hybridization. Nat Biotechnol 17, 87–88 (1999). https://doi.org/10.1038/5270

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