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References
Arathoon, W.R., and Birch, J.R. 1986. Large scale cell culture in biotechnology. Science 232:1390.
Tolbert, W.R., and Srigely, W.R. 1987. Manufacture of pharmacologically active proteins by mammalian cell culture. Biopharm. Manufact. 1:42.
Nilsson, K. 1987. Methods for immobilizing animal cells. Tib Tech. 5:73.
Ku, K., Kuo, M.J., Delente, J., Wildi, B.S., and Feder, J. 1981. Development of a hollow-fiber system for large-scale culture of mammalian cells. Biotechnol. Bioeng. 23:79.
Van Wezel, A.L. 1967. Growth of cell strains and primary cells on microcarriers in homogeneous culture. Nature 216:64.
Young, M.W., and Dean, R.C. 1987. Optimization of mammalian-cell bioreactors. Bio/Technology 5:835.
Goosen, M.F.A., O'shea, G.M., Gharapetian, H.M., Chous, S., and Sun, A.M. 1985. Optimization of microencapsulation parameters: Semipermeable microcapsules as a bioartificial pancreas. Biotechnol. Bioeng. 27:146.
Schreirer, W., Nilsson, K., Merten, O.W., Katinger, H.W.D., and Mosbach, K. 1982. Entrapment of animal cells for the production of biomolecules such as monoclonal antibodies. Develop. Biol. Standard 55:155.
Van Brunt, J. 1987. A closer look at fermentors and bioreactors. Bio/Technology 5:1134.
Familletti, P.C. 1987. U.S. Patent No. 4,649,117.
Familletti, P.C. 1987. Gel immobilized cell culture for monoclonal antibody production. BioPharm. Manufact. (in press).
Knorr, D., Miazga, S.M., and Teutonico, R.A. 1985. Immobilization and permeabilization of cultured plant cells. Food Technol. 39:135.
Chibata, I., and Tosa, T. 1981. Use of immobilized cells. Ann. Rev. Biophys. Bioeng. 10:197.
Shirai, Y., Hashimoto, K., Yamaji, H., and Tokashiki, M. 1987. Continuous production of monoclonal antibody wiih immobilized hybridoma cells in an expanded bed fermentor. Appl. Microbiol. Biotechnol. 26:495.
Staelelin, T., Hobbs, D.D., Kung, H.-F., Lai, C.-Y., and Pestka, S. 1981. Purification and characterization of recombinant human leukocyte interferon (IFLrA) with monoclonal antibody. J. Biol. Chem. 256:9750.
Roy, S.K., McGregor, W.C., and Orichowski, S.T. 1985. Automated high-performance immunosorbent assay for recombinant leukocyte-A interferon. J. Chromatog. 327:189.
Hakimi, J., Seals, C., Anderson, L.E., Podlaski, F.J., Lin, P., Danho, W., Jenson, J.C., Donadio, P.E., Familletti, P.C., Pan, Y.-C.E., Tsien, W.-H., Chizzonite, R.A., Casabo, L., Nelson, D.L., and Cullen, B.R. 1987. Biochemical and functional analysis of soluble human interleukin-2 receptor produced in rodent cells. J. Biol. Chem. (in press).
Bailon, P., Weber, D.V., Keeney, R.F., Fredericks, J.E., Smith, C., Familletti, P.C., and Smart, J.E. 1987. Receptor-affinity chromatography: a one step purification for recombinant interleukin-2. Bio/Technology 5:1195.
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Familletti, P., Fredericks, J. Techniques for Mammalian Cell Immobilization. Nat Biotechnol 6, 41–44 (1988). https://doi.org/10.1038/nbt0188-41
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DOI: https://doi.org/10.1038/nbt0188-41
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