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Proteolytic Processing in the Replication of Polio and Related Viruses

Bio/Technology volume 4, pages 33–42 (1986)Cite this article

Abstract

Recently we have begun to unravel the details of proteolytic processing in picornaviruses. At first, the similarities between these viruses allowed helpful analogies to be drawn between them. Now we are finding that the differences are also important. In the replication of poliovirus and presumably other enteroviruses and rhinoviruses, it appears that all of the processing of the polyprotein results from the activities of viral proteins. Understanding these events may lead to the design of clinically useful specific inhibitors of viral replication.

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Authors and Affiliations

  1. Department of Microbiology, School of Medicine, State University of New York at Stony Brook, Stony Brook, New York, 11794

    Martin J. H. Nicklin, Haruka Toyoda, Michael G. Murray & Eckard Wimmer

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Nicklin, M., Toyoda, H., Murray, M. et al. Proteolytic Processing in the Replication of Polio and Related Viruses. Nat Biotechnol 4, 33–42 (1986). https://doi.org/10.1038/nbt0186-33

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