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Crossing the Rubicon

A viral vector injected intravenously in mice crosses the blood-brain barrier and transduces widespread regions of the brain and spinal cord.

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Figure 1: Developmental changes in the structure of the blood–brain barrier and the brain extracellular matrix likely influence the capacity of AAV9 to transduce different types of brain cells.

Kim Caesar

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Lowenstein, P. Crossing the Rubicon. Nat Biotechnol 27, 42–44 (2009). https://doi.org/10.1038/nbt0109-42

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  • DOI: https://doi.org/10.1038/nbt0109-42

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