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Smart cancer therapy with DNA origami

Tumor infarction is achieved through targeted delivery of thrombin by DNA nanorobots.

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Figure 1: A DNA-origami nanorobot for cancer therapy.


  1. Parodi, A. et al. Biomaterials 147, 155–168 (2017).

    Article  CAS  Google Scholar 

  2. Kumar, V. et al. Theranostics 6, 710–725 (2016).

    Article  CAS  Google Scholar 

  3. Li, S. et al. Nat. Biotechnol. 36, 258–264 (2018).

    Article  CAS  Google Scholar 

  4. Neri, D. & Bicknell, R. Nat. Rev. Cancer 5, 436–446 (2005).

    Article  CAS  Google Scholar 

  5. Rothemund, P.W. Nature 440, 297–302 (2006).

    Article  CAS  Google Scholar 

  6. Kearney, C.J., Lucas, C.R., O'Brien, F.J. & Castro, C.E. Adv. Mater. 28, 5509–5524 (2016).

    Article  CAS  Google Scholar 

  7. Douglas, S.M., Bachelet, I. & Church, G.M. Science 335, 831–834 (2012).

    Article  CAS  Google Scholar 

  8. Jiang, Q. et al. J. Am. Chem. Soc. 134, 13396–13403 (2012).

    Article  CAS  Google Scholar 

  9. Praetorius, F. et al. Nature 552, 84–87 (2017).

    Article  CAS  Google Scholar 

  10. Surana, S., Shenoy, A.R. & Krishnan, Y. Nat. Nanotechnol. 10, 741–747 (2015).

    Article  CAS  Google Scholar 

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Correspondence to Ennio Tasciotti.

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Tasciotti, E. Smart cancer therapy with DNA origami. Nat Biotechnol 36, 234–235 (2018).

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