Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Critical Assessment of Metagenome Interpretation—a benchmark of metagenomics software

Sczyrba, A. et al. Nat. Methods 10.1038/nmeth.4458 (2017).

Enhanced proofreading governs CRISPR–Cas9 targeting accuracy

Chen, J.S. et al. Nature 10.1038/nature24268 (2017).

Engineering quantitative trait variation for crop improvement by genome editing

Rodríguez-Leal, D., Lemmon, Z.H., Man, J., Bartlett, M.E. & Lippman, Z.B. Cell 171, 470–480.e8 (2017).

Driving mosquito refractoriness to Plasmodium falciparum with engineered symbiotic bacteria

Wang, S. et al. Science 357, 1399–1402 (2017).

Changes in the microbiota cause genetically modified Anopheles to spread in a population

Pike, A. et al. Science 357, 1396–1399 (2017).

Graphtyper enables population-scale genotyping using pangenome graphs

Eggertsson, H.P. et al. Nat. Genet. 10.1038/ng.3964 (2017).