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CRISPR–Cas9 claim sets and the potential to stifle innovation

Extremely broad claims surrounding Cas9 nucleases have the potential to stifle innovation in the field of genome editing.

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Figure 1: Schematic overview of Cas9-mediated genome editing.
Figure 2: Percent identities that BLAST hits share with SpCas9.


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Correspondence to W Murray Spruill.

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The authors are employees of Benson Hill Biosystems, which has filed intellectual property on its genome editing technologies.

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Gray, B., Spruill, W. CRISPR–Cas9 claim sets and the potential to stifle innovation. Nat Biotechnol 35, 630–633 (2017).

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