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The impact of personal genomics on risk perceptions and medical decision-making

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Figure 1: Risk perception changes by risk result group.
Figure 2: Risk perception changes by risk result group and medical condition.
Figure 3: Risk perception changes by risk result group and motivation for testing.
Figure 4: Medical utilization according to maximum and median risk perception change.


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We thank Tali Sharot, Alec Brandon, Jean Tirole, Alexandra Rodman, Daniel Fehder, Abhishek Nagaraj, Rebecca Grunberg, Roberto Fernandez, Sarah Kalia and members of the PGen Study Group (particularly Kurt Christensen, Deanna Alexis Carere, and Joanna L. Mountain). Members of the PGen Study Group are listed in Supplementary Note 2. The PGen Study is supported by the US National Institutes of Health (NIH) National Human Genome Research Institute (R01-HG005092). R.C.G. was additionally supported by the following NIH grants: U01-HG006500, U19-HD077671, U01-HG008685 and U41-HG006834.

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Authors and Affiliations



J.L.K. formulated the research question, designed and performed the analyses, prepared the figures and wrote the manuscript. F.M. helped with the research design, analyses, and manuscript writing. R.C.G. and J.S.R. designed and implemented the surveys, in their roles as the primary investigators of the Impact of Personal Genomics (PGen) study, and advised on the preparation of the figures and the manuscript. All authors edited and approved the manuscript.

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Correspondence to Joshua L Krieger.

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Competing interests

R.C.G. receives personal compensation for speaking or consulting from AIA, Helix, Illumina, Invitae, Prudential and Roche.

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Editor's note: This article has been peer-reviewed.

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Supplementary Text and Figures

Supplementary Methods, Supplementary Notes 1 and 2, Supplementary Figures 1–5 and Supplementary Tables 1–9 (PDF 587 kb)

Supplementary Data (XLSX 994 kb)

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Krieger, J., Murray, F., Roberts, J. et al. The impact of personal genomics on risk perceptions and medical decision-making. Nat Biotechnol 34, 912–918 (2016).

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