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Open-source guideseq software for analysis of GUIDE-seq data

Nature Biotechnology volume 34, page 483 (2016) | Download Citation

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References

  1. 1.

    et al. Nat. Biotechnol. 33, 187–197 (2015).

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Acknowledgements

J.K.J. is supported by an NIH Director's Pioneer Award (DP1 GM105378) and the Jim and Ann Orr MGH Research Scholar Award. M.J.A. is supported by the MGH Department of Pathology.

Author information

Author notes

    • Shengdar Q Tsai
    •  & Ved V Topkar

    These authors contributed equally to this work.

Affiliations

  1. Molecular Pathology Unit, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

    • Shengdar Q Tsai
    • , Ved V Topkar
    • , J Keith Joung
    •  & Martin J Aryee
  2. Center for Cancer Research, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

    • Shengdar Q Tsai
    • , Ved V Topkar
    • , J Keith Joung
    •  & Martin J Aryee
  3. Center for Computational and Integrative Biology, Massachusetts General Hospital, Charlestown, Massachusetts, USA.

    • Shengdar Q Tsai
    • , Ved V Topkar
    •  & J Keith Joung
  4. Department of Pathology, Harvard Medical School, Boston, Massachusetts, USA.

    • Shengdar Q Tsai
    • , J Keith Joung
    •  & Martin J Aryee
  5. Department of Biostatistics, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USA.

    • Martin J Aryee

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Competing interests

J.K.J. is a consultant for Horizon Discovery. J.K.J. has financial interests in Editas Medicine, Hera Testing Laboratories, Poseida Therapeutics, and Transposagen Biopharmaceuticals. J.K.J.'s interests were reviewed and are managed by Massachusetts General Hospital and Partners HealthCare in accordance with their conflict of interest policies. S.Q.T., J.K.J. and M.J.A. are co-founders of Beacon Genomics, a company that is commercializing methods for determining nuclease specificity. S.Q.T. and J.K.J. have filed a patent application for the GUIDE-seq method.

Corresponding authors

Correspondence to J Keith Joung or Martin J Aryee.

Supplementary information

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    Supplementary Methods and Supplementary Note

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DOI

https://doi.org/10.1038/nbt.3534

Editor's note: This article has been peer-reviewed.

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