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Genome editing for clinical HIV isolates

An engineered recombinase removes the HIV-1 provirus from patient-derived cells and reduces infection in humanized mice.

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Figure 1: Summary of the current HIV-1 cure strategies and their primary obstacles.


  1. 1

    Finzi, D. et al. Nat. Med. 5, 512–517 (1999).

    CAS  Article  Google Scholar 

  2. 2

    Karpinksi, J.H.I., Chemnitz, J. & Buchholz, F. Nat. Biotechnol. 34, 401–409 (2016).

    Article  Google Scholar 

  3. 3

    Archin, N.M. et al. Nature 487, 482–485 (2012).

    CAS  Article  Google Scholar 

  4. 4

    Tebas, P. et al. N. Engl. J. Med. 370, 901–910 (2014).

    CAS  Article  Google Scholar 

  5. 5

    Hütter, G. et al. N. Engl. J. Med. 360, 692–698 (2009).

    Article  Google Scholar 

  6. 6

    Qu, X. et al. Nucleic Acids Res. 41, 7771–7782 (2013).

    CAS  Article  Google Scholar 

  7. 7

    Ebina, H. et al. PLoS One 10, e0120047 (2015).

    Article  Google Scholar 

  8. 8

    Hu, W. et al. Proc. Natl. Acad. Sci. USA 111, 11461–11466 (2014).

    CAS  Article  Google Scholar 

  9. 9

    Kaminski, R. et al. Sci. Rep. 6, 22555 (2016).

    CAS  Article  Google Scholar 

  10. 10

    Buchholz, F. & Stewart, A.F. Nat. Biotechnol. 19, 1047–1052 (2001).

    CAS  Article  Google Scholar 

  11. 11

    Sarkar, I., Hauber, I., Hauber, J. & Buchholz, F. Science 316, 1912–1915 (2007).

    CAS  Article  Google Scholar 

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Correspondence to Robert F Siliciano.

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The authors declare no competing financial interests.

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Kim, M., Siliciano, R. Genome editing for clinical HIV isolates. Nat Biotechnol 34, 388–389 (2016).

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