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Can CRISPR-Cas9 gene drives curb malaria?

Gene drives in mosquitoes to reduce the spread of malaria move closer, though technical and regulatory hurdles remain.

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Figure 1: Nuclease-based gene drives.

Katie Vicari/Nature Publishing Group

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Correspondence to Luke Alphey.

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LA is a Visiting Professor at the University of Oxford and has equity interest in Intrexon Inc. Both organisations have intellectual property in the area of genetic pest management. LA's research program at the Pirbright Institute aims to develop various genetic pest management approaches with funding from various sources, including BBSRC, Horizon2020 and the Wellcome Trust.

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Alphey, L. Can CRISPR-Cas9 gene drives curb malaria?. Nat Biotechnol 34, 149–150 (2016). https://doi.org/10.1038/nbt.3473

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