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Availability and payer coverage of BRCA1/2 tests and gene panels

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Figure 1: Pricing for BRCA1/2-only and panel tests.


  1. Curnutte, M.A., Frumovitz, K.L., Bollinger, J.M., McGuire, A.L. & Kaufman, D.J. Nat. Biotechnol. 32, 980–982 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Ratner, M. Nat. Biotechnol. 31, 663–665 (2013).

    Article  CAS  PubMed  Google Scholar 

  3. Weldon, C.B., Trosman, J.R., Gradishar, W.J., Benson, A.B. III & Schink, J.C. J. Oncol. Pract. 8, e24–31 (2012).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Trosman, J.R., Van Bebber, S.L. & Phillips, K.A. J. Oncol. Pract. 7, 18s–24s (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  5. Daly, M. et al. NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines) Genetic/Familial High-Risk Assessment: Breast and Ovarian (version 2.2105). (2015). Accessed July 19, 2015.

  6. Graf, M.D., Needham, D.F., Teed, N. & Brown, T. Per. Med. 10, 235–243 (2013).

    Article  CAS  PubMed  Google Scholar 

  7. Wang, G., Beattie, M.S., Ponce, N.A. & Phillips, K.A. Genet. Med. 13, 1045–1050 (2011).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Heger, M. Official Discusses Wash U's Successful Strategy in Developing a Reimbursable NGS Cancer Test. (2014). Accessed June 30, 2014.

  9. Trosman, J.R., Weldon, C.B., Kelley, R.K. & Phillips, K.A. J. Natl. Compr. Canc. Netw. 13, 311–318 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  10. Kurian, A.W. et al. J. Clin. Oncol. 32, 2001–2009 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Domchek, S.M., Bradbury, A., Garber, J.E., Offit, K. & Robson, M.E. J. Clin. Oncol. 31, 1267–1270 (2013).

    Article  PubMed  Google Scholar 

  12. Kurian, A.W., Kingham, K.E. & Ford, J.M. Curr. Opin. Obstet. Gynecol. 27, 23–33 (2015).

    Article  PubMed  Google Scholar 

  13. Turnbull, C. & Rahman, N. Annu. Rev. Genomics Hum. Genet. 9, 321–345 (2008).

    Article  CAS  PubMed  Google Scholar 

  14. Couch, F.J., Nathanson, K.L. & Offit, K. Science (New York, N.Y.) 343, 1466–1470 (2014).

    Article  CAS  Google Scholar 

  15. Hiraki, S., Rinella, E.S., Schnabel, F., Oratz, R. & Ostrer, H. J. Genet. Couns. 23, 604–617 (2014)

    Article  PubMed  Google Scholar 

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This study was partially funded by a National Human Genome Research Institute grant to K.A.P. (R01HG007063), a National Cancer Institute grant to the University of California at San Francisco (UCSF), Helen Diller Family Comprehensive Cancer Center (5P30CA082013-15) and the UCSF Mount Zion Health Fund. E.C. received Summer Research Fellowship funds from the Albert Einstein College of Medicine in support of this study.

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Correspondence to Kathryn A Phillips.

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K.A.P. has received honoraria for speaking at a professional conference session sponsored by Invitae. Disclosures have been reviewed by the University of California, San Francisco. J.T. and C.W. both received funding from an unrestricted grant from Myriad Genetics.

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Clain, E., Trosman, J., Douglas, M. et al. Availability and payer coverage of BRCA1/2 tests and gene panels. Nat Biotechnol 33, 900–902 (2015).

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