Papers from the literature selected by the Nature Biotechnology editors. (Follow us on Twitter, @NatureBiotech #nbtHighlight)

Genome-wide CRISPR screen in a mouse model of tumor growth and metastasis

Chen, S. et al. Cell 160, 1246–1260 (2015)

The genetic architecture of the human immune system: a bioresource for autoimmunity and disease pathogenesis

Roederer, M. et al. Cell 161, 387–403 (2015)

Identification of a large set of rare complete human knockouts

Sulem, P. et al. Nat. Genet. doi:10.1038/ng.3243 (25 March 2015)

Structural imprints in vivo decode RNA regulatory mechanisms

Spitale, R.C. et al. Nature 519, 486–490 (2015)

The mutagenic chain reaction: a method for converting heterozygous to homozygous mutations

Gantz, V. et al. Science, doi:10.1126/science.aaa5945 (19 March 2015)

Soft, curved electrode systems capable of integration on the auricle as a persistent brain–computer interface

Norton, J.J.S. et al. PNAS 112, 3920–3925 (2015)