Taking charge of siRNA delivery

  • A Corrigendum to this article was published on 12 May 2015

Delivery of siRNA into cells is achieved by neutralizing the negative charge of the phosphate backbone in a reversible manner.

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Figure 1: Internalization and cellular processing of TAT-conjugated siRNN.

Change history

  • 29 April 2015

    In the version of this article initially published, in two instances molecules were misidentified in the text. The last sentence in the legend of Figure 1 should have read, “a charged phosphodiester,” rather than “a phosphatediester.” On p.1197, third column, first paragraph, “intracellular phosphodiesterases….” should have read, “intracellular thioesterases….” The errors have been corrected in the HTML and PDF versions of the article.


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Correspondence to Anastasia Khvorova.

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Khvorova, A., Osborn, M. & Hassler, M. Taking charge of siRNA delivery. Nat Biotechnol 32, 1197–1198 (2014). https://doi.org/10.1038/nbt.3091

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