Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

PIQ-ing into chromatin architecture

Nature Biotechnology volume 32, pages 138–140 (2014)Cite this article

Subjects

Decrypting the logic of gene regulation is aided by a breakthrough method for analyzing chromatin-accessibility data.

This is a preview of subscription content, access via your institution

Access options

Buy this article

  • Purchase on Springer Link
  • Instant access to full article PDF
Buy now

Prices may be subject to local taxes which are calculated during checkout

Figure 1: Hierarchical binding of transcription factors regulates gene expression.
Figure 2: PIQ improves the identification of occupied transcription factor (TF) binding sites in vivo from genome-wide DNase I hypersensitivity data.

References

  1. Sherwood, R.I. et al. Nat. Biotechnol. 32, 171–178 (2014).

    Article  CAS  Google Scholar 

  2. Zaret, K.S. & Carroll, J.S. Genes Dev. 25, 2227–2241 (2011).

    Article  CAS  Google Scholar 

  3. Boyle, A.P. et al. Cell 132, 311–322 (2008).

    Article  CAS  Google Scholar 

  4. Pique-Regi, R. et al. Genome Res. 21, 447–455 2011).

    Article  CAS  Google Scholar 

  5. Neph, S. et al. Nature 489, 83–90 (2012).

    Article  CAS  Google Scholar 

  6. ENCODE Project Consortium. et al. Nature. 447, 799–816 (2007).

  7. Soufi, A., Donahue, G. & Zaret, K.S. Cell 151, 994–1004 (2012).

    Article  CAS  Google Scholar 

  8. Yang, Y.P. & Wright, C. Nat. Chem. Biol. 5, 195–196 (2009).

    Article  CAS  Google Scholar 

  9. Rais, Y. et al. Nature 502, 65–70 (2013).

    Article  CAS  Google Scholar 

  10. Taberlay, P.C. et al. Cell 147, 1283–1294 (2011).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Sebastian Rieck and Christopher Wright are at the Department of Cell and Developmental Biology, Center for Stem Cell Biology and Program in Developmental Biology, Vanderbilt University, Nashville, Tennessee, USA.,

    Sebastian Rieck & Christopher Wright

Authors
  1. Sebastian Rieck
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Christopher Wright
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Christopher Wright.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Rieck, S., Wright, C. PIQ-ing into chromatin architecture. Nat Biotechnol 32, 138–140 (2014). https://doi.org/10.1038/nbt.2824

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2824

Search

Advanced search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research