Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

Reprogramming paces the heart

Rodent cardiomyocytes are converted into pacemaker cells by viral delivery of a single transcription-factor gene.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: The coupled-clock pacemaker 'symphony'.

Katie Vicari

References

  1. Kapoor, N., Liang, W., Marbán, E. & Cho, H.C. Nat. Biotechnol. 31, 54–62 (2013).

    Article  CAS  Google Scholar 

  2. Rosen, M.R., Robinson, R.B., Brink, P.R. & Cohen, I.S. Nat. Rev. Cardiol. 8, 656–666 (2011).

    Article  Google Scholar 

  3. Qu, J. et al. Circulation 107, 1106–1109 (2003).

    Article  Google Scholar 

  4. Miake, J., Marban, E. & Nuss, H.B. Nature 419, 132–133 (2002).

    Article  CAS  Google Scholar 

  5. Lakatta, E.G., Maltsev, V.A. & Vinogradova, T.M. Circ. Res. 106, 659–673 (2010).

    Article  CAS  Google Scholar 

  6. Edelberg, J.M., Aird, W.C. & Rosenberg, R.D. J. Clin. Invest. 101, 337–343 (1998).

    Article  CAS  Google Scholar 

  7. Boink, G.J. et al. Circulation 126, 528–536 (2012).

    Article  CAS  Google Scholar 

  8. Bakker, M.L. et al. Cardiovasc. Res. 94, 439–449 (2012).

    Article  CAS  Google Scholar 

  9. Conkright, M.D. & Montminy, M. Trends Cell Biol. 15, 457–459 (2005).

    Article  CAS  Google Scholar 

  10. Ebert, S.N., Rong, Q., Boe, S. & Pfeifer, K. Ann. NY Acad. Sci. 1148, 317–324 (2008).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding authors

Correspondence to Edward G Lakatta or Victor A Maltsev.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Lakatta, E., Maltsev, V. Reprogramming paces the heart. Nat Biotechnol 31, 31–32 (2013). https://doi.org/10.1038/nbt.2480

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nbt.2480

Search

Quick links

Nature Briefing: Translational Research

Sign up for the Nature Briefing: Translational Research newsletter — top stories in biotechnology, drug discovery and pharma.

Get what matters in translational research, free to your inbox weekly. Sign up for Nature Briefing: Translational Research