Genome remodeling

Article metrics

Alteration of a stop codon across an entire bacterial genome opens the way to exploring the biotech potential of synthetic genetic codes.

Access optionsAccess options

Rent or Buy article

Get time limited or full article access on ReadCube.

from$8.99

All prices are NET prices.

Figure 1: Simplified illustration of in vivo genome-wide codon replacement.

References

  1. 1

    Benner, S.A. & Sismour, A.M. Nat. Rev. Genet. 6, 533–543 (2005).

  2. 2

    Gibson, D. et al. Science 329, 52–56 (2010).

  3. 3

    Dymond, J.S. et al. Nature doi:10.1038/nature10403 (in the press).

  4. 4

    Isaacs, F.J. et al. Science 333, 348–353 (2011).

  5. 5

    Wang, H.H. et al. Nature 460, 894–898 (2009).

  6. 6

    Mukai, T. et al. Nucleic Acids Res. 38, 8188–8195 (2010).

  7. 7

    Sawitzke, J.A. et al. J. Mol. Biol. 407, 45–59 (2011).

  8. 8

    Liu, C.C. & Schultz, P.G. Annu. Rev. Biochem. 79, 413–444 (2010).

  9. 9

    Kawakami, K. et al. Genetics 131, 821–832 (1992).

Download references

Author information

Correspondence to Jef D Boeke.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and Permissions

About this article