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Biomarkers in aggregate

Nature Biotechnology volume 29, pages 236–237 (2011)Cite this article

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Implantable devices that measure the cumulative release of biomarkers promise new diagnostic options.

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Figure 1: The aggregation of functionalized superparamagnetic iron oxide nanoparticles, also called magnetic relaxation switches (MRSw), in the presence of biomarkers decreases the transverse relaxivity (T2) of surrounding water protons, generating a signal detectable using magnetic resonance relaxometry.

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Authors and Affiliations

  1. Fred S. Apple is in the Department of Laboratory Medicine and Pathology, University of Minnesota School of Medicine and Hennepin County Medical Center, Minneapolis, Minnesota, USA.,

    Fred S Apple

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  1. Fred S Apple
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Correspondence to Fred S Apple.

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Competing interests

F.S.A. has consulted for and received research grant funding for several biomarker companies that market the biomarkers discussed in the paper reviewed. These include Abbott Diagnostics, Beckman Coulter, Siemens, Ortho-Clinical Diagnostics, Radiometer, Roche, BRAHMS, Alere/Biosite and Response Biomedical.

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Apple, F. Biomarkers in aggregate. Nat Biotechnol 29, 236–237 (2011). https://doi.org/10.1038/nbt.1803

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