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We. acknowledge funding from the UK Natural Environmental Research Council's Environmental Bioinformatics Centre and the UK Biotechnology and Biological Sciences Research Council (BB/E025080/1) to D.F. and S.-A.S. to support C.F.T. and MIBBI. Work on MIFlowCyt is supported by the US National Institutes of Health's National Institute of Biomedical Imaging and Bioengineering (EB005034-01) and by Bioinformatics Integration Support Contract A140076 from the US National Institute of Allergy and Infectious Diseases. R.R.B. is supported by the Michael Smith Foundation for Health Research, by the International Society for the Advancement of Cytology and by grant funding from the US National Institute of Biomedical Imaging and Bioengineering, National Institutes of Health (R01EB005034). N.W.H. acknowledges the support of the European Union Framework VI project META-PHOR (Food-ST-2006-03622). F.G., P.L. and work on CARMEN are supported by the UK Engineering and Physical Sciences Research Council (EP/E002331/1). K.T. acknowledges support from Science Foundation Ireland. Work on MIAME/Tox and MIAME/Nutr by P.R-S. is supported by the NuGO (NoE 503630) and CarcinoGenomics (PL 037712) European Union projects. Work on MIARE is supported by the eDIKT project. Opinions, findings and conclusions or recommendations expressed in this paper are those of the authors and do not necessarily reflect the views of the US National Science Foundation or the US National Institutes of Health.

Author information


  1. European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SD, UK.

    • Chris F Taylor
    • , Susanna-Assunta Sansone
    • , Rolf Apweiler
    • , Alvis Brazma
    • , Henning Hermjakob
    • , Nicolas Le Novère
    • , Sandra Orchard
    • , Philippe Rocca-Serra
    • , Daniel Schober
    •  & Peter Sterk
  2. Natural Environment Research Council Environmental Bioinformatics Centre, Mansfield Road, Oxford OX1 3SR, UK.

    • Chris F Taylor
    • , Dawn Field
    • , Susanna-Assunta Sansone
    • , Tim Booth
    • , Tanya Gray
    •  & Norman Morrison
  3. Molecular Evolution and Bioinformatics Group, Oxford Centre for Ecology and Hydrology, Mansfield Road, Oxford OX1 3SR, UK.

    • Dawn Field
    •  & Tanya Gray
  4. Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridgeshire CB10 1SA, UK.

    • Jan Aerts
  5. Department of Genetics, University of Cambridge, Downing Street, Cambridge CB2 3EH, UK.

    • Michael Ashburner
  6. Stanford Microarray Database, Department of Biochemistry, Stanford University School of Medicine, Stanford, California 94305-5307, USA.

    • Catherine A Ball
  7. Swiss Institute of Bioinformatics, Michel-Servet 1, 1211 Geneva, Switzerland.

    • Pierre-Alain Binz
  8. Geneva Bioinformatics (GeneBio) SA, Avenue de Champel 25, 1206 Geneva, Switzerland.

    • Pierre-Alain Binz
  9. Jax Mouse Phenome Project, The Jackson Laboratory, 600 Main Street, Bar Harbor, Maine 04609, USA.

    • Molly Bogue
  10. Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver V5Z 1L3, British Columbia, Canada.

    • Ryan R Brinkman
  11. The Lance Armstrong Foundation, PO Box 161150, Austin, Texas 78716-1150, USA.

    • Adam Michael Clark
  12. Institute for Systems Biology, 1441 N. 34th Street, Seattle, Washington 98103, USA.

    • Eric W Deutsch
  13. University of California Davis, Genome Center, 451 East Health Sciences Drive, Davis, California 95616, USA.

    • Oliver Fiehn
  14. National Institute of Environmental Health Sciences and Lockheed Martin Information Technology, Research Triangle Park, North Carolina 27709-2233, USA.

    • Jennifer Fostel
  15. Division of Pathway Medicine, University of Edinburgh Medical School, The Chancellor's Building, Little France Crescent, Edinburgh EH16 4SB, UK.

    • Peter Ghazal
    • , Graeme Grimes
    •  & Javier Santoyo-Lopez
  16. School of Computing Science, Newcastle University, Newcastle upon Tyne NE1 7RU, UK.

    • Frank Gibson
    •  & Phillip Lord
  17. Bioinformatics Group, Medical Research Council Mammalian Genetics Unit, Harwell, Oxfordshire OX11 0RD, UK.

    • John M Hancock
    •  & Ann-Marie Mallon
  18. Department of Computer Science, Aberystwyth University, Penglais, Aberystwyth SY23 3DB, UK.

    • Nigel W Hardy
  19. Indigo BioSystems, Inc., 111 Congressional Boulevard, Suite 160, Carmel, Indiana 46032, USA.

    • Randall K Julian Jr
  20. Division of Molecular and Cellular Biosciences, National Science Foundation, 4201 Wilson Boulevard, Arlington, Virginia 22230, USA.

    • Matthew Kane
  21. Beilstein-Institut zur Förderung der Chemischen Wissenschaften, Trakehner Strasse 7-9, D-60487 Frankfurt am Main, Germany.

    • Carsten Kettner
  22. Office of Technology and Industrial Relations, Office of the Director, National Cancer Institute, Bldg 31A, Rm 10A52, Bethesda, Maryland 20892, USA.

    • Christopher Kinsinger
    •  & Henry Rodriguez
  23. Seattle Children's Hospital Research Institute, 1900 9th Avenue, Seattle, Washington 98101, USA.

    • Eugene Kolker
  24. Seattle Children's Hospital and Regional Medical Center, 4800 Sand Point Way NE, Seattle, Washington 98105, USA.

    • Eugene Kolker
  25. Department of Plant Systems Biology, Vlaams Instituut voor Biotechnologie, Technologiepark 927, B-9052 Ghent, Belgium; Molecular Genetics, Ghent University, B-9052 Ghent, Belgium; and Department of Biology, Norwegian University of Science and Technology, N-7491 Trondheim, Norway.

    • Martin Kuiper
  26. Department of Plant Biology, University of Georgia, Athens, Georgia 30602-7271, USA.

    • Jim Leebens-Mack
  27. Department of Molecular and Cellular Biology, Life Sciences Addition, University of California, Berkeley, California 94729-3200, USA.

    • Suzanna E Lewis
  28. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390 USA.

    • Nishanth Marthandan
    •  & Richard H Scheuermann
  29. RIKEN Genomic Sciences Center, 3-1-1 Koyadai, Tsukuba-shi, Ibaraki 305-0074 Japan.

    • Hiroshi Masuya
  30. Economic and Social Research Council Centre for Economic and Social Aspects of Genomics (Cesagen), Lancaster University, Institute for Advanced Studies, IAS Building, County South, Lancaster LA1 4YD, UK.

    • Ruth McNally
  31. Division of Molecular Genome Analysis, German Cancer Research Center, Im Neuenheimer Feld 580, 69120 Heidelberg, Germany.

    • Alexander Mehrle
    • , Heiko Rosenfelder
    •  & Stefan Wiemann
  32. School of Computer Science, University of Manchester, Oxford Road, Manchester M13 9PL, UK.

    • Norman Morrison
  33. Department of Biostatistics and Computational Biology and Department of Cancer Biology, Dana-Farber Cancer Institute, Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts 02115, USA.

    • John Quackenbush
  34. Department of Animal Science, Center for Integrated Animal Genomics, Iowa State University, 2255 Kildee Hall, Ames, Iowa 50011-3150, USA.

    • James M Reecy
  35. Bristol-Myers Squibb, Route 206 & Province Line Road, Princeton, New Jersey 08543-4000, USA.

    • Donald G Robertson
  36. NuGO, The European Nutrigenomics Organisation (

    • Philippe Rocca-Serra
  37. Department of Philosophy and Center of Excellence in Bioinformatics and Life Sciences, University at Buffalo, New York 14260, USA.

    • Barry Smith
  38. AstraZeneca UK Ltd., Brixham, Devon TQ5 8BA, UK.

    • Jason Snape
  39. Department of Genetics, Center for Bioinformatics, 423 Guardian Drive, Philadelphia, Pennsylvania 19104-6021, USA.

    • Christian J Stoeckert Jr
  40. School of Biochemistry and Immunology, Trinity College Dublin, College Green, Dublin 2, Ireland.

    • Keith Tipton
  41. Laboratory of Molecular Biology, Department of Plant Science, Wageningen University, The Netherlands.

    • Andreas Untergasser
  42. Center for Medical Genetics, Ghent University Hospital, 9000 Ghent, Belgium.

    • Jo Vandesompele


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Competing interests

D.F., S.-A.S. and C.F.T. conceived and designed the concept of MIBBI as synergistic project; D.F. and S.-A.S. raised the funds to support MIBBI activities, and C.F.T. performed the analysis presented in this paper; all authors discussed the results and implications and commented on the manuscript.

Corresponding authors

Correspondence to Chris F Taylor or Dawn Field or Susanna-Assunta Sansone.

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