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Cancer

Division hierarchy leads to cell heterogeneity

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Cellular diversity can hamper cancer treatment. Analysis of tumour cell-division patterns now reveals how such heterogeneity can arise by a hierarchical pattern of stem-cell divisions yielding a mosaic of different cells. See Article p.227

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Figure 1: Tracking cellular heterogeneity in cancer.

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Correspondence to Joan Seoane.

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Seoane, J. Division hierarchy leads to cell heterogeneity. Nature 549, 164–166 (2017). https://doi.org/10.1038/nature23546

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