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Heart disease

Putative medicines that mimic mutations

Nature volume 548, pages 530–531 (2017)Cite this article

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Molecules that block the activity or production of the protein ANGPTL3 have now been found to lower blood levels of lipoproteins and cholesterol in mice and healthy humans, mimicking the protective effects of genetic mutations in ANGPTL3.

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Figure 1: Triglyceride-rich lipoproteins and the risk of heart attack.

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Authors and Affiliations

  1. Center for Genomic Medicine, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    Sekar Kathiresan

  2. Cardiovascular Disease Initiative, Broad Institute, Cambridge, Massachusetts

    Sekar Kathiresan

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  1. Sekar Kathiresan
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Correspondence to Sekar Kathiresan.

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Kathiresan, S. Putative medicines that mimic mutations. Nature 548, 530–531 (2017). https://doi.org/10.1038/nature23544

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