Effects of a ketamine metabolite on synaptic NMDAR function

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Figure 1: (2R,6R)-HNK blocks NMDAR-mEPSCs and decreases eEF2 phosphorylation in hippocampal neurons.
Figure 2: (2R,6R)-HNK acts as open channel NMDAR blocker.


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Correspondence to Lisa M. Monteggia.

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Suzuki, K., Nosyreva, E., Hunt, K. et al. Effects of a ketamine metabolite on synaptic NMDAR function. Nature 546, E1–E3 (2017). https://doi.org/10.1038/nature22084

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