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Lifespan effects of mitochondrial mutations

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Figure 1: Healthspan study in the conplastic strain C57BL/6J-mtNZB/BlnJ (mtNZB/BlnJ) and in C57BL/6J (mtC57BL/6J) control mice.


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Authors and Affiliations



M.H. and S.M.I. designed the study. M.H., P.S. and C.S. performed the experiments and analysed the data. M.W. and A.Z. conducted the statistical analysis of the survival data. Y.G. analysed the sequencing data. O.J. performed the indirect calorimetric cage experiment and analysed the data. M.H., A.E.W., M.R. and S.M.I. wrote the manuscript with contributions from all other authors. S.M.I. directed the study.

Corresponding author

Correspondence to Saleh M. Ibrahim.

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The authors declare no competing financial interests.

Extended data figures and tables

Extended Data Figure 1 Indirect calorimetric cage analysis of mtC57BL/6J and mtNZB/BlnJ mice.

a, Spontaneous locomotor activities. b, Area under the curve analysis of the activities shown in a. c, Area under the curve of respiratory exchange ratio (RER) and energy expenditure (EE). Data were obtained from 5 female mtC57BL/6J mice and 6 female mtNZB/BlnJ mice.

Extended Data Table 1 Statistical analysis for the lifespan of mtC57BL/6J and mtNZB/BlnJ mice
Extended Data Table 2 Sequence difference between mtDNA of mtNZB/BlnJ and mtC57BL/6J mice

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Supplementary Information

This file contains Supplementary Data Table 1, Supplementary Methods and Supplementary References. (PDF 215 kb)

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Hirose, M., Schilf, P., Gupta, Y. et al. Lifespan effects of mitochondrial mutations. Nature 540, E13–E14 (2016).

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