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Lifespan effects of mitochondrial mutations

Nature volume 540, pages E13E14 (15 December 2016) | Download Citation

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Author information

Affiliations

  1. Lübeck Institute of Experimental Dermatology, University of Lübeck, Germany

    • Misa Hirose
    • , Paul Schilf
    • , Yask Gupta
    •  & Saleh M. Ibrahim
  2. Institute of Medical Biometry and Statistics, University of Lübeck, University Medical Center Schleswig-Holstein, Campus Lübeck, Germany

    • Marvin N. Wright
    •  & Andreas Ziegler
  3. Institute of Experimental and Clinical Pharmacology and Toxicology, University of Lübeck, Lübeck, Germany

    • Olaf Jöhren
  4. Center of Brain, Behavior and Metabolism (CBBM), University of Lübeck, Lübeck, Germany

    • Olaf Jöhren
  5. Institute of Nutritional Medicine, University of Lübeck, Lübeck, Germany

    • Anika E. Wagner
    •  & Christian Sina
  6. ZKS Lübeck, University of Lübeck, Lübeck, Germany

    • Andreas Ziegler
  7. School of Mathematics, Statistics and Computer Science, University of KwaZulu-Natal, Pietermaritzburg, South Africa

    • Andreas Ziegler
  8. Energy Metabolism Laboratory, Swiss Federal Institute of Technology (ETH) Zurich, Schwerzenbach, Switzerland

    • Michael Ristow

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Contributions

M.H. and S.M.I. designed the study. M.H., P.S. and C.S. performed the experiments and analysed the data. M.W. and A.Z. conducted the statistical analysis of the survival data. Y.G. analysed the sequencing data. O.J. performed the indirect calorimetric cage experiment and analysed the data. M.H., A.E.W., M.R. and S.M.I. wrote the manuscript with contributions from all other authors. S.M.I. directed the study.

Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Saleh M. Ibrahim.

Extended data

Supplementary information

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    Supplementary Information

    This file contains Supplementary Data Table 1, Supplementary Methods and Supplementary References.

About this article

Publication history

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Published

DOI

https://doi.org/10.1038/nature20778

Further reading

  • Low-level mitochondrial heteroplasmy modulates DNA replication, glucose metabolism and lifespan in mice

    • Misa Hirose
    • , Paul Schilf
    • , Yask Gupta
    • , Kim Zarse
    • , Axel Künstner
    • , Anke Fähnrich
    • , Hauke Busch
    • , Junping Yin
    • , Marvin N. Wright
    • , Andreas Ziegler
    • , Marie Vallier
    • , Meriem Belheouane
    • , John F Baines
    • , Diethard Tautz
    • , Kornelia Johann
    • , Rebecca Oelkrug
    • , Jens Mittag
    • , Hendrik Lehnert
    • , Alaa Othman
    • , Olaf Jöhren
    • , Markus Schwaninger
    • , Cornelia Prehn
    • , Jerzy Adamski
    • , Kensuke Shima
    • , Jan Rupp
    • , Robert Häsler
    • , Georg Fuellen
    • , Rüdiger Köhling
    • , Michael Ristow
    •  & Saleh M. Ibrahim

    Scientific Reports (2018)

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