Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

Cardiovascular disease

A turbulent path to plaque formation

Plaque deposits often occur in curved arterial regions with turbulent blood flow. Endothelial cells have been found to respond to blood flow through a previously unidentified signalling pathway that affects plaque build-up. See Letter p.579

This is a preview of subscription content, access via your institution

Access options

Buy article

Get time limited or full article access on ReadCube.

$32.00

All prices are NET prices.

Figure 1: Endothelial-cell signalling can affect plaque formation.

Notes

  1. See all news & views

References

  1. Caro, C. G., Fitz-Gerald, J. M. & Schroter, R. C. Nature 223, 1159–1161 (1969).

    Article  CAS  ADS  Google Scholar 

  2. Ross, R. N. N. Engl. J. Med. 340, 115–126 (1999).

    Article  CAS  Google Scholar 

  3. Wang, L. et al. Nature 540, 579–582 (2016).

    Article  CAS  ADS  Google Scholar 

  4. Chatzizisis, Y. S., Coskun, A. U., Jonas, M., Edelman, E. R., Feldman, C. L. & Stone, P. H. J. Am. Coll. Cardiol. 49, 2379–2393 (2007).

    Article  CAS  Google Scholar 

  5. Dupont, S. et al. Nature 474, 179–183 (2011).

    Article  CAS  Google Scholar 

  6. Piccolo, S., Dupont, S. & Cordenonsi, M. Physiol. Rev. 94, 1287–1312 (2014).

    Article  CAS  Google Scholar 

  7. Schober, J. M. et al. Blood 99, 4457–4465 (2002).

    Article  CAS  Google Scholar 

  8. Chaqour, B. & Goppelt-Struebe, M. FEBS J. 273, 3639–3649 (2006).

    Article  CAS  Google Scholar 

  9. Zhou, J. et al. Proc. Natl Acad. Sci. USA 109, 7770–7775 (2012).

    Article  CAS  ADS  Google Scholar 

  10. Zhang, S. H., Reddick, R. L., Burkey, B. & Maeda, N. J. Clin. Invest. 94, 937–945 (1994).

    Article  CAS  Google Scholar 

  11. Nam, D. et al. Am. J. Physiol. Heart Circ. Physiol. 297, H1535–H1543 (2009).

    Article  CAS  Google Scholar 

  12. Chen, J., Green, J., Yurdagul, A. Jr, Albert, P., McInnis, M. C. & Orr, A. W. Am. J. Pathol. 185, 2575–2589 (2015).

    Article  CAS  Google Scholar 

  13. Maile, L. A. et al. Sci. Transl. Med. 2, 18ra11 (2010).

    Article  Google Scholar 

  14. Hoshiga, M., Alpers, C. E., Smith, L. L., Giachelli, C. M. & Schwartz, S. M. Circ. Res. 77, 1129–1135 (1995).

    Article  CAS  Google Scholar 

  15. Sorrentino, G. et al. Nature Cell Biol. 16, 357–366 (2014).

    Article  CAS  Google Scholar 

  16. Wang, Z. et al. Proc. Natl Acad. Sci. USA 111, E89–E98 (2014).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ellie Tzima.

Related links

Related links

Related links in Nature Research

Heart disease: Death-defying plaque cells

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Mehta, V., Tzima, E. A turbulent path to plaque formation. Nature 540, 531–532 (2016). https://doi.org/10.1038/nature20489

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/nature20489

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing