Activation of aged muscle stem cells induces changes in DNA packaging that lead to expression of the gene Hoxa9. This reactivates embryonic signalling pathways, restricting the cells' ability to repair injured muscle. See Letter p.428
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Eliazer, S., Brack, A. Cause and consequence in aged-muscle decline. Nature 540, 349–350 (2016). https://doi.org/10.1038/nature20485
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DOI: https://doi.org/10.1038/nature20485
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