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In retrospect

Eighty years of stress

The discovery in 1936 that rats respond to various damaging stimuli with a general response that involves alarm, resistance and exhaustion launched the discipline of stress research.

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Figure 1: Hans Selye outlines the general adaptation syndrome.

Don Graham/Division de la Gestion de Documents et des Archives, Univ. Montréal

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References

  1. Selye, H. Nature 138, 32 (1936).

    Article  ADS  Google Scholar 

  2. Selye, H. Br. Med. J. 1, 1383–1392 (1950).

    Article  CAS  Google Scholar 

  3. Bernard, C. Leçons sur les propriétés physiologiques et les altérations pathologiques des liquides de l'organisme (Baillière, 1859).

    Google Scholar 

  4. Cannon, W. B. The Wisdom of the Body (Norton, 1932).

    Book  Google Scholar 

  5. Sherwin, R. R. & Sacca, L. Am. J. Physiol. Endocrinol. Metab. 245, E157–E165 (1984).

    Article  Google Scholar 

  6. Selye, H. J. Hum. Stress 1, 37–44 (1975).

    Article  CAS  Google Scholar 

  7. Selye, H. Stress in Health and Disease (Butterworth, 1976).

    Google Scholar 

  8. Haslbeck, M. & Vierling, E. J. Mol. Biol. 427, 1537–1548 (2015).

    Article  CAS  Google Scholar 

  9. Park, C.-J. & Seo, Y.-S. Plant Pathol. J. 31, 323–333 (2015).

    Article  CAS  Google Scholar 

  10. Pacak, K. et al. Am. J. Physiol. 275, R1247–R1255 (1998).

    Article  CAS  Google Scholar 

  11. Sterling, P. & Eyer, J. in Handbook of Life Stress, Cognition and Health (eds Fisher, S. & Reason, J.) 629–649 (Wiley, 1988).

    Google Scholar 

  12. Schulkin, J. (ed.) Allostasis, Homeostasis, and the Costs of Physiological Adaptation (Cambridge Univ. Press, 2004).

    Book  Google Scholar 

  13. McEwen, B. S. Physiol. Rev. 87, 873–904 (2007).

    Article  Google Scholar 

  14. Vale, W., Spiess, J., Rivier, C. & Rivier, J. Science 213, 1394–1397 (1981).

    Article  ADS  CAS  Google Scholar 

  15. Fink, G. J. Neuroendocrinol. 23, 107–117 (2011).

    Article  CAS  Google Scholar 

Download references

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Fink, G. Eighty years of stress. Nature 539, 175–176 (2016). https://doi.org/10.1038/nature20473

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