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Sleepy and dreamless mutant mice

Sleep in mammals consists of non-rapid-eye-movement and rapid-eye-movement sleep. A large genetic screen reveals that these two sleep states are altered in mice by mutations dubbed Sleepy and Dreamless. See Article p.378

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Figure 1: Screening sleep.


  1. 1.

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  1. 1

    Funato, H. et al. Nature 539, 378–383 (2016).

    ADS  CAS  Article  Google Scholar 

  2. 2

    Vitaterna, M. H. et al. Science 264, 719–725 (1994).

    ADS  CAS  Article  Google Scholar 

  3. 3

    Franken, P., Malafosse, A. & Tafti, M. Sleep 22, 155–169 (1999).

    CAS  PubMed  Google Scholar 

  4. 4

    Franken, P. & Dijk, D. J. Eur. J. Neurosci. 29, 1820–1829 (2009).

    CAS  Article  Google Scholar 

  5. 5

    Baylor, G. W. & Cavallero, C. Sleep 24, 165–170 (2001).

    CAS  PubMed  Google Scholar 

  6. 6

    Flourakis, M. et al. Cell 162, 836–848 (2015).

    CAS  Article  Google Scholar 

  7. 7

    Dijk, D. J. & Czeisler, C. A. J. Neurosci. 15, 3526–3538 (1995).

    CAS  Article  Google Scholar 

  8. 8

    Krueger, J. M., Frank, M. G., Wisor, J. P. & Roy, S. Sleep Med. Rev. 28, 46–54 (2016).

    Article  Google Scholar 

  9. 9

    Billiard, M. & Sonka, K. Sleep Med. Rev. 29, 23–33 (2016).

    Article  Google Scholar 

  10. 10

    Scullin, M. K. & Bliwise, D. L. Sleep 38, 335–336 (2015).

    Article  Google Scholar 

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Correspondence to Derk-Jan Dijk or Raphaëlle Winsky-Sommerer.

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Dijk, DJ., Winsky-Sommerer, R. Sleepy and dreamless mutant mice. Nature 539, 364–365 (2016).

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