Expression of a blood-cancer-associated genetic mutation in the non-blood cells of the bone marrow is sufficient to cause blood cancer in mice. This finding could point to new approaches to treating an often-fatal disease. See Letter p.304
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Chang, T. Y., Dvorak, C. C. & Loh, M. L. Blood 124, 2487–2497 (2014).
Dong, L. et al. Nature 539, 304–308 (2016).
Chan, G. & Neel, B. G. in Protein Tyrosine Phosphatases in Cancer (eds Neel, B. G. & Tonks, N. K.) 115–143 (Springer, 2016).
Roberts, A. E., Allanson, J. E., Tartaglia, M. & Gelb, B. D. Lancet 381, 333–342 (2013).
Mohi, M. G. et al. Cancer Cell 7, 179–191 (2005).
Xu, D. et al. J. Exp. Med. 208, 1977–1988 (2011).
Hoggatt, J., Kfoury, Y. & Scadden, D. T. Annu. Rev. Pathol. 11, 555–581 (2016).
Walkley, C. R., Shea, J. M., Sims, N. A., Purton, L. E. & Orkin, S. H. Cell 129, 1081–1095 (2007).
Woollard, S. M. & Kanmogne, G. D. Drug Des. Dev. Ther. 9, 5447–5468 (2015).
Shalapour, S. & Karin, M. J. Clin. Invest. 125, 3347–3355 (2015).
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Chan, G., Neel, B. Bad neighbours cause bad blood. Nature 539, 173–175 (2016). https://doi.org/10.1038/nature19479
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DOI: https://doi.org/10.1038/nature19479