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Mammalian development

Mechanics drives cell differentiation

Several hypotheses have been formulated to explain how cells make the first lineage decision during mammalian embryonic development. An overarching mechanism now unifies these disparate models. See Letter p.344

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Figure 1: A fateful decision.

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Correspondence to Berenika Plusa or Anna-Katerina Hadjantonakis.

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Plusa, B., Hadjantonakis, AK. Mechanics drives cell differentiation. Nature 536, 281–282 (2016). https://doi.org/10.1038/nature18920

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