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Synthetic biology

Bacteria synchronized for drug delivery

A synthetic genetic circuit that mimics the quorum-sensing systems used by bacterial populations to coordinate gene expression enables bacteria to deliver drugs to mouse tumours in repeated and synchronized cycles. See Letter p.81

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Figure 1: Synchronized cyclical lysis and drug release.

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Correspondence to Shibin Zhou.

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Competing interests

Under a licensing agreement between BioMed Valley Discoveries Inc. and the Johns Hopkins University, S.Z. is entitled to a share of royalties received by the University on sales of products related to therapy using C. novyi-NT bacteria. The terms of the arrangement are under ongoing management by the Johns Hopkins University in accordance with its conflict of interest policies.

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Zhou, S. Bacteria synchronized for drug delivery. Nature 536, 33–34 (2016). https://doi.org/10.1038/nature18915

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