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Depression

Ketamine steps out of the darkness

The way in which ketamine exerts its antidepressant effects has been perplexing. Evidence that a metabolite of the drug is responsible, and acts on a different target from ketamine, might be the key to an answer. See Article p.481

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Figure 1: Metabolite mediator of ketamine.

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Correspondence to Roberto Malinow.

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Malinow, R. Ketamine steps out of the darkness. Nature 533, 477–478 (2016). https://doi.org/10.1038/nature17897

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