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Untangling autism

A clever dissection of the roles of the Ptchd1 gene in the brains of mice demonstrates one way to untangle the complex relationships between the causes and symptoms of neurodevelopmental disorders. See Article p.58

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Figure 1: Tracing the threads between causes and symptoms of autism.


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  1. Wells, M. F., Wimmer, R. D., Schmitt, L. I., Feng, G. & Halassa, M. M. Nature 532, 58–63 (2016).

    ADS  CAS  Article  Google Scholar 

  2. Coe, B. P., Girirajan, S. & Eichler, E. E. Curr. Opin. Neurobiol. 22, 829–836 (2012).

    CAS  Article  Google Scholar 

  3. Pinto, D. et al. Nature 466, 368–372 (2010).

    ADS  CAS  Article  Google Scholar 

  4. Noor, A. et al. Sci. Transl. Med 2, 49ra68 (2010).

    Article  Google Scholar 

  5. Chaudhry, A. et al. Clin. Genet. 88, 224–233 (2015).

    CAS  Article  Google Scholar 

  6. Barthó, P. et al. Neuron 82, 1367–1379 (2014).

    Article  Google Scholar 

  7. Wimmer, R. D. et al. Nature 526, 705–709 (2015).

    ADS  CAS  Article  Google Scholar 

  8. McAlonan, K., Cavanaugh, J. & Wurtz, R. H. Nature 456, 391–394 (2008).

    ADS  CAS  Article  Google Scholar 

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Correspondence to Joshua A. Gordon.

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Bolkan, S., Gordon, J. Untangling autism. Nature 532, 45–46 (2016).

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