The part that the mouse gene Prdm9 plays in generating double-strand breaks in DNA has now been linked to its putative role in speciation, thanks to experiments that use a 'humanized' version of the gene. See Article p.171
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Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J. C. & Forejt, J. Science 323, 373–375 (2009).
Davies, B. et al. Nature 530, 171–176 (2016).
Bhattacharyya, T. et al. Proc. Natl Acad. Sci. USA 110, e468–e477 (2013).
Bhattacharyya, T. et al. PLoS Genet. 10, e1004088 (2014).
Baudat, F., Imai, Y. & de Massy, B. Nature Rev. Genet. 14, 794–806 (2013).
Myers, S. et al. Science 327, 876–879 (2010).
Maheshwari, S. & Barbash, D. A. Annu. Rev. Genet. 45, 331–355 (2011).
Buard, J. et al. PLoS ONE 9, e85021 (2014).
Kono, H. et al. DNA Res. 21, 315–326 (2014).
Oliver, P. L. et al. PLoS Genet. 5, e1000753 (2009).
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Forejt, J. Asymmetric breaks in DNA cause sterility. Nature 530, 167–168 (2016). https://doi.org/10.1038/nature16870
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DOI: https://doi.org/10.1038/nature16870
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Evolution of the recombination regulator PRDM9 in minke whales
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