Skip to main content

Thank you for visiting You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.


Asymmetric breaks in DNA cause sterility

The part that the mouse gene Prdm9 plays in generating double-strand breaks in DNA has now been linked to its putative role in speciation, thanks to experiments that use a 'humanized' version of the gene. See Article p.171

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Buy article

Get time limited or full article access on ReadCube.


All prices are NET prices.


  1. See all news & views


  1. Mihola, O., Trachtulec, Z., Vlcek, C., Schimenti, J. C. & Forejt, J. Science 323, 373–375 (2009).

    ADS  CAS  Article  Google Scholar 

  2. Davies, B. et al. Nature 530, 171–176 (2016).

    ADS  CAS  Article  Google Scholar 

  3. Bhattacharyya, T. et al. Proc. Natl Acad. Sci. USA 110, e468–e477 (2013).

    CAS  Article  Google Scholar 

  4. Bhattacharyya, T. et al. PLoS Genet. 10, e1004088 (2014).

    Article  Google Scholar 

  5. Baudat, F., Imai, Y. & de Massy, B. Nature Rev. Genet. 14, 794–806 (2013).

    CAS  Article  Google Scholar 

  6. Myers, S. et al. Science 327, 876–879 (2010).

    ADS  CAS  Article  Google Scholar 

  7. Maheshwari, S. & Barbash, D. A. Annu. Rev. Genet. 45, 331–355 (2011).

    CAS  Article  Google Scholar 

  8. Buard, J. et al. PLoS ONE 9, e85021 (2014).

    ADS  Article  Google Scholar 

  9. Kono, H. et al. DNA Res. 21, 315–326 (2014).

    CAS  Article  Google Scholar 

  10. Oliver, P. L. et al. PLoS Genet. 5, e1000753 (2009).

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations


Corresponding author

Correspondence to Jiri Forejt.

Related links

Related links

Related links in Nature Research

Evolutionary genetics: Origins of reproductive isolation

Rights and permissions

Reprints and Permissions

About this article

Verify currency and authenticity via CrossMark

Cite this article

Forejt, J. Asymmetric breaks in DNA cause sterility. Nature 530, 167–168 (2016).

Download citation

  • Published:

  • Issue Date:

  • DOI:

Further reading


Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing