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Repositioned to kill stem cells


Chemotherapy-resistant cancer stem cells make it hard to cure many forms of the disease. Repositioning an existing drug to tackle this problem could significantly improve treatment for one form of leukaemia. See Letter p.380

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Figure 1: Targeting leukaemic stem cells in chronic myeloid leukaemia.


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  1. Prost, S. et al. Nature 525, 380–383 (2015).

    Article  ADS  CAS  Google Scholar 

  2. Daley, G. Q., Van Etten, R. A. & Baltimore, D. Science 247, 824–830 (1990).

    Article  ADS  CAS  Google Scholar 

  3. Kranc, K. R. et al. Cell Stem Cell 5, 659–665 (2009).

    Article  CAS  Google Scholar 

  4. Ito, K. et al. Nature 453, 1072–1078 (2008).

    Article  ADS  CAS  Google Scholar 

  5. Bellodi, C. et al. J. Clin. Invest. 119, 1109–1123 (2009).

    Article  CAS  Google Scholar 

  6. Pemovska, T. et al. Nature 519, 102–105 (2015).

    Article  ADS  CAS  Google Scholar 

  7. Prost, S. et al. J. Clin. Invest. 118, 1765–1775 (2008).

    CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Tessa Holyoake or David Vetrie.

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Holyoake, T., Vetrie, D. Repositioned to kill stem cells. Nature 525, 328–329 (2015).

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