New findings implicate the enzyme lysyl oxidase (LOX), secreted by oxygen-deprived breast cancer cells, in inducing bone lesions that precede and facilitate the spread of the cancer cells to the bone. See Letter p.106
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Bone metastasis is associated with acquisition of mesenchymal phenotype and immune suppression in a model of spontaneous breast cancer metastasis
Scientific Reports Open Access 14 August 2020
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Erez, N. Opening LOX to metastasis. Nature 522, 41–42 (2015). https://doi.org/10.1038/nature14529